A reassessment of the Lewy body.
Identifieur interne : 002A02 ( Main/Exploration ); précédent : 002A01; suivant : 002A03A reassessment of the Lewy body.
Auteurs : Wing Lok Au [Canada] ; Donald B. CalneSource :
- Acta neurologica Taiwanica [ 1028-768X ] ; 2005.
English descriptors
- KwdEn :
- Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Lewy Bodies (pathology), Lewy Bodies (physiology), Nerve Tissue Proteins (analysis), Parkinson Disease (diagnosis), Parkinson Disease (genetics), Parkinson Disease (pathology), Protein-Serine-Threonine Kinases (genetics), Synucleins, tau Proteins (analysis).
- MESH :
- chemical , analysis : Nerve Tissue Proteins, tau Proteins.
- chemical , genetics : Protein-Serine-Threonine Kinases.
- chemical : Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Synucleins.
- diagnosis : Parkinson Disease.
- genetics : Parkinson Disease.
- pathology : Lewy Bodies, Parkinson Disease.
- physiology : Lewy Bodies.
- Humans.
Abstract
Lewy body has been linked to Parkinson's disease for almost a century, but its significance in neurodegenerative diseases is not known. Whether it is toxic, protective, or just a bystander has been a subject of debate. Recent advances in molecular and genetic works suggest Lewy bodies are not essential for the diagnosis and pathogenesis of Parkinson's disease. Furthermore, the discovery of gene mutations in PARK8, an autosomal-dominant late-onset parkinsonism with pleomorphic pathology, suggests the clinical expression of neurodegenerative diseases depends more on the anatomical pathways affected rather than any particular "pathological marker".
PubMed: 16008161
Affiliations:
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Le document en format XML
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Calne</name></author></analytic><series><title level="j">Acta neurologica Taiwanica</title><idno type="ISSN">1028-768X</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Lewy Bodies (pathology)</term><term>Lewy Bodies (physiology)</term><term>Nerve Tissue Proteins (analysis)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Synucleins</term><term>tau Proteins (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nerve Tissue Proteins</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Synucleins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lewy Bodies</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lewy Bodies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lewy body has been linked to Parkinson's disease for almost a century, but its significance in neurodegenerative diseases is not known. Whether it is toxic, protective, or just a bystander has been a subject of debate. Recent advances in molecular and genetic works suggest Lewy bodies are not essential for the diagnosis and pathogenesis of Parkinson's disease. Furthermore, the discovery of gene mutations in PARK8, an autosomal-dominant late-onset parkinsonism with pleomorphic pathology, suggests the clinical expression of neurodegenerative diseases depends more on the anatomical pathways affected rather than any particular "pathological marker".</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B" last="Calne">Donald B. Calne</name></noCountry><country name="Canada"><noRegion><name sortKey="Au, Wing Lok" sort="Au, Wing Lok" uniqKey="Au W" first="Wing Lok" last="Au">Wing Lok Au</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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